标 题：
How to read DNA?
时 间： 2019 年 10 月 9 日 15 : 30 - 16 : 30
地 点： 新光电大楼会议室 C112
报告人： Pro. Ralph Scheicher ，Department of Physics and Astronomy, Uppsala University
邀请人： 何毓辉 教授
报告摘要：
How to read DNA?
A seemingly simple question, but the answer is complex. We have known about the structure of DNA for less than seven decades, since Crick and Watson first determined its double helix shape and the four-letters “alphabet” constituting its base pairs, A-T and G-C. For an even shorter period of time have we been able to “read” DNA, meaning that we can determine the sequence of its base letters in one strand of the double helix molecule (for example, ATGCTTCGGCAAGACTTCA). Since the initial applications of the original reading method, tremendous improvements have occurred in terms of how fast and especially at how low a cost we can determine long DNA sequences. From hundreds of millions of US Dollars 20 years ago, we have seen a truly unparalleled drop in cost, down to about merely one thousand US Dollars for a single human genome! Yet, the quest is far from over, and we continue to push for even lower prices and even faster read-out techniques.
A physical approach to DNA sequencing has many advantages over the prevalent chemical ones. Nanogaps and nanopores, in particular, have been widely studied in this regard, for their application to sequencing. The presentation will highlight how theoretical and computational methods can contribute to the progress in this research field, to develop the next generation in nano-bio technology that can show us how to read DNA.
报告人介绍
Dr. Scheicher is now Assistant Professor in Department of Physics and Astronomy, Uppsala University. Prof. Scheicher received his Bachelor’s degree from the University of Würzburg in Germany and his Ph.D degree in physics from the State University of New York at Albany. He also received the Distinguished Doctoral Dissertation Award at the same year. He spent two years as a visiting assistant professor in the Department of Physics at Michigan Technological University where he was giving lectures and conducted his research in the Computational Solid State Theory & Materials Science Group. He was then invited to be a guest researcher in Uppsala University in the Condensed Matter Theory Group (now part of the Division of Materials Theory) working with Prof. Rajeev Ahuja. As of July 2010, He has joined the faculty of the Department of Physics and Astronomy at Uppsala University as an assistant professor. Prof. Scheicher was awarded the Benzelius Prize by the Royal Society of Sciences in Uppsala in 2011, for his contributions to the use of molecular electronics to sequence DNA using nanopores in graphene. His published DNA+CNT article has ranked the majority of the time among the Top 10 most cited papers published in the journal Nanotechnology during the period 2008 till present. Prof. Scheicher has published more than 100 SCI Journal papers, and his research work has obtained more than 3000 non-self-citations with H index of 28.
