报告人：Prof. Gary Tearney, Harvard University (Gary Tearney教授，哈佛大学医学院)
时间：2013年05月28日10:00-11:00
地点：华中科技大学南五楼613会议室
Abstract:
Today's gold standard for medical diagnosis is histology of excised biopsies or surgical specimens where tissue is taken out of the body, processed, sectioned, stained and looked at under a light microscope by a pathologist. There are many limitations of this technique, including the fact that it is inherently invasive, time consuming, costly, and dangerous for some organs. Furthermore, oftentimes the diseased tissue is not readily seen by visual inspection and as a result the tissue is sampled at a random location, which can be highly inaccurate. If we could instead conduct microscopy inside the body, then we could provide tools for screening, targeting biopsies, making primary disease diagnosis, and guiding intervention on the cellular basis. This promise has motivated the development of a new field, termed in vivo microscopy, the goal of which is to obtain microscopic images from living human patients. Two in vivo microscopy technologies, confocal microscopy and optical coherence tomography, are currently available and in clinical use. Upcoming developments, including whole organ microscopy, swallowable microscopy capsules, molecular imaging, and very high resolution microscopic devices are in the pipeline and will likely revolutionize how disease is diagnosed and how medicine is practiced in the future.
Biography:
His research interests are primarily focused on the development and validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. In particular, he has conducted research to develop and establish a new imaging modality, termed “optical coherence tomography” (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He was the first to perform human imaging in the coronary arteries and gastrointestinal tract with this method, and his laboratory has imaged over 500 patients to date. Additionally, he has developed an endoscopic confocal microscopy system that is capable of obtaining images at a resolution of 1.0 μm through an endoscope accessory port. Images obtained by OCT and endoscopic confocal microscopy may be used to guide biopsies during screening procedures and may potentially allow for primary diagnosis at tissue sites where excisional biopsies are difficult to obtain. He has developed several other technologies, including an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and imaging techniques. He has an active program in Raman spectroscopy and have conducted the first intracoronary Raman in vivo. He has successfully transitioned several inventions into the commercial sector. Examples include the rapidly scanning optical delay line (RSOD) that is utilized for ophthalmic OCT and optical frequency domain imaging (OFDI) technology that is being commercialized by multiple companies for intracoronary and gastrointestinal uses.
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